Termitomyces microcarpus is the most popular mushroom amongst consumers in Uganda, for its nutritional and medical uses. An experiment was carried out to demonstrate food supplemental benefits of Termitomyces microcarpus using Rattus rattus as in-vivo models. A completely randomized design was used with four experimental treatments. These contained basal feed diets supplemented with pre-cooked sun-dried mushroom flour and heat steamed mushroom flour (25%, n=20 and 50%, n=20) and control group (n=10) .The objectives of the study were to determine the differences in feed intake between the diets with raw and steamed T. microcarpus and to determine the effect of mushroom inclusion on weight gain and heamatological characteristics using Rattus rattus as a model. The hypothesis tested was that dietary supplementation with raw and steamed Termitomyces microcarpus (Obubaala), improves growth and heamatological indices of Rattus rattus; and that growth and heamatological indices of Rattus rattus are independent of mushroom processing treatment. Weende System was used in proximate analysis of mushrooms diets were formulated. Feeding trials were carried out for a week before start of actual experimentation and data collection. The daily feed offers and refusals were quantified and post weaning performance, individual feed intakes were recorded for 6 weeks. At the end of the dietary regimen, weight gains, feed intake, and heamatological indices were measured. Statistical analysis of data was performed using the Sigma- stat System. Kruskal-Wallis one-way ANOVA was run for descriptive statistics, followed by Dunn's Pairwise comparisons to test significant differences (p=0.05) among groups. Results were presented as means ± SD. Difference in mean values among the groups for the feed intake, weight gain or growth and heamatological indices were statistically significant (P=
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