In order to determine the seroprevalence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections in Cameroon, a prospective cohort study was carried out in Laquintinie Hospital, Douala, Cameroon. From January 2005 to February 2006, a total of 14,742 familial and volunteer blood donors and 311 people living with HIV/AIDS were screened both for antigens/antibodies to HIV and HCV. The results obtained show that 851 (5.77%) of the 14,742 blood donors enrolled were positive for HIV; 362 (2.45%) were positive for HCV; and 22 (0.15%) were positive for both HIV and HCV. Moreover, from 311 people living with HIV/AIDS, 14 (4.50%) were positive for HCV. Mean age for HIV positive participants was significantly low compared to HCV positive participants. In addition, HIV mono-infected patients were younger than HIV/HCV co-infected patients. Therefore, HIV infection was more prevalent in Douala than HCV infection. HCV infected people were older than HIV mono-infected patients.
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